SEPT7

Available structures

PDB
Ortholog search: PDBe RCSB

List of PDB id codes

2QAG, 3T5D, 3TW4

Identifiers

Aliases
SEPT7, CDC10, CDC3, NBLA02942, SEPT7A, septin 7

External IDs
MGI: 1335094 HomoloGene: 1354 GeneCards: SEPT7

Gene ontology

Molecular function
• nucleotide binding
• GTP binding
• structural molecule activity
• protein binding
• identical protein binding
• cadherin binding involved in cell-cell adhesion

Cellular component
• condensed chromosome kinetochore
• cytosol
• cell projection
• spindle
• cilium
• septin complex
• stress fiber
• chromosome
• midbody
• apical plasma membrane
• axoneme
• cleavage furrow
• chromosome, centromeric region
• cytoskeleton
• extracellular exosome
• nucleus
• kinetochore
• cell-cell adherens junction
• cytoplasm
• sperm annulus
• non-motile cilium

Biological process
• cilium morphogenesis
• mitotic nuclear division
• protein heterooligomerization
• cytokinesis
• regulation of embryonic cell shape
• cell division
• positive regulation of non-motile cilium assembly
• cell cycle
• cell-cell adhesion
• spermatogenesis
• cell differentiation

Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species
Human
Mouse

Entrez

989

235072

Ensembl

ENSG00000122545

ENSMUSG00000001833

UniProt

Q16181

O55131

RefSeq (mRNA)

NM_001011553
NM_001242956
NM_001788

NM_001205367
NM_009859

RefSeq (protein)

NP_001011553
NP_001229885
NP_001779

NP_001192296.1
NP_001192296
NP_033989

Location (UCSC)
Chr 7: 35.8 – 35.91 Mb
Chr 9: 25.25 – 25.31 Mb

PubMed search
[1]
[2]

Wikidata

View/Edit Human
View/Edit Mouse

Septin-7 is a protein that in humans is encoded by the SEPT7 gene.[3][4]

Contents

1 Function
2 Interactions
3 References
4 Further reading

Function[edit]
This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. Although the exact function of this gene has not yet been det